Title
Cancer Target Discovery and Development Network (U01)
Agencies
National Institutes of Health (NIH)
Description
This Funding Opportunity Announcement (FOA) will continue to support the program "Cancer Target Discovery and Development†(CTD^2, pronounced cee-tee-dee-squared). CTD^2 is focused on efforts that advance cancer research by bridging the knowledge gap between the rapidly increasing volumes of new data generated by comprehensive molecular characterizations of many cancer types and studies of the underlying etiology of cancer development, progression, and/or metastasis.
The primary purpose of the CTD^2 program is to advance our understanding of cancer etiology, mechanisms and treatment through:
Improving the understanding of how mutations in cancer genes affect the downstream functions (e.g., gain-of-function, loss-of-function, or neomorphic function) within the protein and cellular pathway(s);
Searching for new molecular targets with the goal to overcome innate and/or acquired resistance to therapies, particularly clinical resistance related to inter- and intra- tumor heterogeneity; and
Developing efficient strategies to identify appropriate multiple targets and optimal combination of perturbagens (chemical or biological; immunotherapeutics being a prime example of the latter) with the potential to eliminate all cancer cells, despite their clonal heterogeneity.
This FOA solicits applications for research projects advancing the goals outlined above. The proposed projects should use a combination of state-of-the-art high throughput informatic and experimental approaches to address at a minimum two of these three research areas: (1) characterization and validation of novel cancer targets; (2) identification of molecular markers that can meaningfully predict responses or resistance to anticancer therapies; and (3) development of perturbagens that can affect the proposed targets of cancer treatment.
More Information
http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-16-014.html
Submission Limits
Applicant organization may submit two applications, provided that each application is scientifically distinct and based on different self-standing project (although, if desired and appropriate, these two projects may be designed as a broadly-based interactive effort).
Deadlines
Internal Notice of Intent |
Aug 4, 2016 |
Notification of Internal Competition |
Aug 5, 2016 |
Internal Pre-proposal |
Aug 12, 2016 |
Results of Internal Competition |
Aug 19, 2016 |
Agency Notice of Intent/Pre-proposal |
Sep 3, 2016 |
Agency Proposal |
Oct 3, 2016
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