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The Major Research Instrumentation Program (MRI) is designed to increase access to scientific and engineering equipment for research and research training in our Nation’s organizations of higher education, research museums and non-profit research organizations.

This program seeks to improve the quality and expand the scope of research and research training in science and engineering, and to foster the integration of research and education by providing instrumentation for research-intensive learning environments. The MRI program encourages the development and acquisition of research instrumentation for shared inter- or intra-organizational use and in concert with private sector partners.

The MRI program assists in the acquisition or development of major research instrumentation by organizations that is, in general, too costly for support through other NSF programs. Proposals may be for a single instrument, a large system of instruments, or multiple instruments that share a common or specific research focus. Title VII of the America COMPETES Act (P.L. 110-69) directs the National Science Foundation to require cost-sharing in the Major Research Instrumentation (MRI) Program of at least 30%. The Act states that institutions of higher education that are not Ph.D.-granting institutions are exempt from the cost-sharing requirement. Therefore, effective FY 2008, the MRI Program will require 30% cost-sharing on all proposals submitted by PhD granting institutions and non degree-granting institutions. The latter category includes US independent research museums, US independent nonprofit research organizations and consortia whose members consist of US institutions of higher education and/or US independent research museums. Cost-sharing will not be required from non PhD-granting institutions. Contributions towards cost-sharing may be made from any non-Federal source, and may be cash or in-kind. No exceptions will be made for this cost-sharing requirement.

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The Burroughs Wellcome Fund's (BWF's) The Investigators in the Pathogenesis of Infectious Disease program provides opportunities for assistant professors to bring multidisciplinary approaches to the study of human infectious diseases. The goal of the program is to provide opportunities for accomplished investigators still early in their careers to study the pathogenesis of infectious disease at its most fundamental level - the points where human and microbial systems connect. The program supports research that sheds light on the fundamentals that affect the outcomes of this encounter: how colonization, infection, commensalism, and other relationships play out at levels ranging from molecular interactions to systemic ones. BWF is particularly interested in work focused on the host, as well as host-pathogen studies originating in viral, bacterial, fungal, or parasite systems. Studies supported by the program may have their roots in the pathogen, but the focus of the work should be on the interplay of host and microbe. The program emphasizes areas of research that open up unexplored areas of pathogenesis. Research on understudied infectious diseases, including pathogenic fungi, protozoan and metazoan diseases, and emerging infections, is especially of interest. In addition, excellent animal models of human disease, including work done in veterinary research settings, are within the program's scope. Interdisciplinary approaches are encouraged.

The awards are intended to give recipients the freedom and flexibility to pursue high-risk projects and new avenues of inquiry. Work supported will be efforts that have the potential to significantly advance the understanding of how microbes and the human system interact, especially in the context of infection. Biochemical, pharmacological, molecular, genetic, immunologic, and other approaches are all appropriate for support by the program. Areas of particular interest include - cell/pathogen interactions: studies of host responses at the cell surface, cell signaling in response to infection, microbial persistence in host cells, and other work; - host/pathogen interactions: studies of how host genetics influences resistance and susceptibility to infection, innate and adaptive immune responses to microbes, pathogen modulation of the immune system, and other work); and - novel routes to disease causation: studies of the role of infectious agents in the etiology of chronic, autoimmune, and immunologic diseases, and other work.

Approaches that fit into these frameworks might include the study of host susceptibility to particular pathogens, host resistance to chronic or acute disease, or basic studies of infectious microbes - as long as the work is oriented toward understanding how the organism interacts with the host. Virulence factors, immune mechanisms, and genetic studies in microbes and the host all provide fertile ground for this kind of study.

Work on AIDS, malaria, tuberculosis, and organisms of interest for bio-defense may be submitted, but nominating institutions should note that research on under-funded and understudied organisms is especially of interest: proposed work in well-funded systems may be viewed as less relevant to the program's goals.

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NSF’s five-year goal for high performance computing (HPC) is to enable petascale science and engineering through the deployment and support of a world-class HPC environment comprising the most capable combination of HPC assets available to the academic community. By the year 2010, the petascale HPC environment will enable investigations of computationally challenging problems that require computing systems capable of delivering sustained performance approaching 1015 floating point operations per second (petaflops) on real applications, that consume large amounts of memory, and/or that work with very large data sets. Among other things, researchers will be able to perform simulations that are intrinsically multi-scale or that involve the simultaneous interaction of multiple processes.

The purpose of this solicitation is to generate proposals from resource provider organizations who are committed to the acquisition and deployment of balanced HPC systems that will contribute to the development of the HPC environment described above. In future competitions, these systems will be upgraded or complemented by the acquisition of additional HPC systems that may be optimized for particular classes of science and engineering research problems. However, this competition emphasizes the provision of one or two well-balanced systems that deliver high levels of performance for many different types of science and engineering applications.

• Enable researchers to work on a range of computationally-challenging science and engineering applications;
• Incorporate reliable, robust system software essential to optimal sustained performance; and
• Provide a high degree of stability and usability.

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The Instrumentation for Materials Research - Major Instrumentation Project (IMR-MIP) program in the Division of Materials Research provides support for the design and construction of major instruments costing more than $2 million at major U.S. facilities. The program also supports the development of detailed conceptual and engineering design for new tools for materials preparation or characterization at major national facilities. Such instruments may include, for example, neutron beam lines, synchrotron beam lines, and high field magnets, as well as development of detectors and preparation environments necessary to support materials research.

The program supports two types of awards: Conceptual and Engineering Design (CED) awards and Construction (CNST) awards. A CED award will enable the proposer to do the necessary engineering design of the instrument. A CNST proposal may only be submitted after a satisfactory engineering design of the instrument has been completed and has been approved by both the facility at which the instrument will be situated and by NSF. The program does not provide operating funds for projects it supports through this solicitation.

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Funding will not be considered for:

• general institutional expenses;
• general fundraising campaign expenses such as dinners and mass mailings;
• as a contribution to unified funds or to a pooled fund that is itself used to award grants of any kind; and
• social science, religious, political, or other research that does not fall within the foundation's areas of interest, as described above.

The BYI program is open to persons with tenure-track appointments in academic and nonprofit institutions that conduct fundamental research in the chemical and life sciences. Candidates must be citizens or permanent residents of the United States at the time of application. Documentation of U.S. citizenship (copy of birth certificate or passport) or permanent residency status must be provided with the application. Persons who have applied for permanent residency but have not received their government documentation by the time of application are not eligible.

To be eligible, an applicant should not have completed more than three full years in his or her tenure-track or other comparable independent research appointment. Regardless of eligibility under this rule, no individual may apply for a Beckman Young Investigator award more than three times.

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• provide resources to support and advance research that will improve understanding of the antecedents and consequences of population structure and change;
• facilitate interdisciplinary collaboration among investigators conducting population-related research and in allied fields; and
• promote innovative approaches to population research questions. An additional goal is to facilitate interactions among scientists in locations throughout the United States that contribute to the integration and coordination of population research.

1. Research on the antecedents and consequences of changes in population size, structure, and composition
2. Demographic, social science, and behavioral science research on families and households
3. Demographic, social science, and behavioral science research on fertility
4. Research on population movement and distribution
5. Demographic and social science research on health, morbidity, disability, health disparities, and mortality
6. Demographic, social science, and behavioral science research on the sexual transmission of HIV and other sexually transmitted diseases
7. For other specific diseases and conditions not mentioned above, research that primarily focuses on the social, cultural, familial, and economic determinants and consequences of these diseases and conditions

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The purpose of this Funding Opportunity Announcement (FOA) is to provide short-term infrastructure support for established population centers and programs that are doing research in the areas within the mission of the National Institute of Child Health and Human Development's (NICHD's) Demographic and Behavioral Sciences Branch (DBSB). The centers to be supported by this program have a solid base in population research, are on a trajectory to become more productive and influential in population research, and, with the infrastructure support provided through this program, are likely to be competitive for a Population Research Infrastructure Program (R24) award within three to five years.

• provide resources to support and advance research that will improve understanding of the antecedents and consequences of population structure and change;
• facilitate interdisciplinary collaboration among investigators conducting population-related research and in allied fields; and
• promote innovative approaches to population research questions. An additional goal is to facilitate interactions among scientists in locations throughout the United States that contribute to the integration and coordination of population research.

1. Research on the antecedents and consequences of changes in population size, structure, and composition
2. Demographic, social science, and behavioral science research on families and households
3. Demographic, social science, and behavioral science research on fertility
4. Research on population movement and distribution
5. Demographic and social science research on health, morbidity, disability, health disparities, and mortality
6. Demographic, social science, and behavioral science research on the sexual transmission of HIV and other sexually transmitted diseases
7. For other specific diseases and conditions not mentioned above, research that primarily focuses on the social, cultural, familial, and economic determinants and consequences of these diseases and conditions

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Planning Grants: Proposals must be submitted on the same deadline dates as those indicated above for Preliminary Proposals, following discussion with a Program Officer.

Conference, Symposia, and Workshop Grants: Proposals may be submitted at any time, generally at least one year in advance, following discussion with a Program Officer. These types of projects do not require Preliminary Proposals.

Grants Supplements for Existing ISE Awards: Requests must be submitted at least two months prior to the need for additional funds, following discussion with the Cognizant Program Officer.

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PI Eligibility Limit: An individual may be included as a Principal Investigator (PI) in no more than the following numbers of proposals under ISE consideration at the same time, as follows: one Full Proposal for a Project Grant; one Preliminary Proposal for the next round of Project Grants; one Planning Grant proposal; and one Conference, Symposia, and Workshop Grant Proposal. However, a PI in one proposal may be a Co-Principal Investigator or project team member on other proposals submitted to this Solicitation.

Limit on Number of Proposals: An institution or organization may serve as lead in no more than the following numbers of proposals under ISE consideration at the same time: three Preliminary Proposals and three Full Proposals for Project Grants; three proposals in total for Planning Grants and/or Conference, Symposia, and Workshop Grants. A proposal that is substantially similar to another proposal from the same institution or organization that is under consideration by ISE or other NSF program will be returned without review.

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