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The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for Center Core Grants to support neuroscience research. The purpose of this program is to advance the NINDS mission to promote understanding and treatment of neurological disorders by providing core research facilities that are not otherwise available. This support, by providing more accessible resources, is expected to assure a greater productivity than would be possible from the separate projects. An applicant organization is eligible for a maximum of one NINDS Center Core Grant.

NINDS Center Core Grants will support centralized resources and facilities shared by investigators with existing NINDS-funded research projects. Each center will be composed of one or more research cores, each of which will enrich the effectiveness of ongoing research, and promote new research directions. A Center Core Grant will support individual neuroscience research projects by providing necessary resources and performing required services that would be difficult or impractical to provide in individual labs. Center Core Grants will foster a cooperative and interactive research environment through which multidisciplinary approaches to neuroscience problems and joint research efforts will be stimulated. The applicant organization is encouraged to consider a plan to co-fund the center, in order to maximize its utility and effectiveness.

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The Federal Cyber Service: Scholarship for Service (SFS) program seeks to increase the number of qualified students entering the fields of information assurance and computer security and to increase the capacity of the United States higher education enterprise to continue to produce professionals in these fields to meet the needs of our increasingly technological society. The SFS program is composed of two tracks: the Scholarship Track and the Capacity Building Track.

The Scholarship Track provides funding to colleges and universities to award scholarships to students in the information assurance and computer security fields. Scholarship recipients shall pursue academic programs in information assurance for the final two years of undergraduate study, or for two years of master's-level study, or for the final two years of Ph.D.-level study. These students will participate as a cohort during their two years of study and activities, including a summer internship in the Federal Government. A limited number of students may be placed in National Laboratories and Federally Funded Research and Development Centers (FFRDCs). This number shall be set by the program office each year. (See http://www.firstgov.gov/Agencies/federal.shtml for a list of Federal organizations, see http://www.science.doe.gov/National_Laboratories/ for a list of National Laboratories, see http://www.nsf.gov/statistics/nsf05306/ for a list of FFRDCs.) The recipients of the scholarships will become part of the Federal Cyber Service of Information Technology Specialists whose responsibility is to ensure the protection of the United States Government's information infrastructure. Upon graduation, after their two-year scholarships, recipients will be required to work for two years in the Federal Government. A limited number of students may be placed in National Laboratories and Federally Funded Research and Development Centers (FFRDCs). This number shall be set by the program office each year.

The Capacity Building Track provides funds to colleges and universities to improve the quality and increase the production of information assurance and computer security professionals. Professional development of information assurance faculty and development of academic programs can be funded under this track.

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Computing has permeated and in many cases transformed almost all aspects of our everyday lives. As computing becomes more important in all sectors of society, so does the preparation of a globally competitive U.S. workforce with knowledge and understanding of critical computing concepts, methodologies, and techniques. Unfortunately, despite the deep and pervasive impact of computing and the creative efforts of individuals in a small number of institutions, undergraduate computing education today often looks much as it did several decades ago.

Through the CISE Pathways to Revitalized Undergraduate Computing Education (CPATH) program, NSF's Directorate for Computer and Information Science and Engineering (CISE) is challenging its partners – colleges, universities and other stakeholders committed to advancing the field of computing and its impact - to transform undergraduate computing education on a national scale, to meet the challenges and opportunities of a world where computing is essential to U.S. leadership and economic competitiveness across all sectors of society.

The CPATH vision is of a U.S. workforce with the computing competencies and skills imperative to the Nation’s health, security and prosperity in the 21st century. This workforce includes a cadre of computing professionals prepared to contribute to sustained U.S. leadership in computing in a wide range of application domains and career fields, and a broader professional workforce with knowledge and understanding of critical computing concepts, methodologies and techniques.

To achieve this vision, CISE is calling for colleges and universities to work together, and with other stakeholders in undergraduate computing education including industry, professional societies and other types of organizations, to formulate and implement plans to revitalize undergraduate computing education in the United States. The full engagement of faculty and other individuals in CISE disciplines will be critical to success. Common challenges - such as fluctuating enrollments in traditional computer science programs, changes and trends in workforce demographics, the imperative to integrate fast-paced computing innovations into the curriculum, and the need to integrate computing concepts and methodologies into the undergraduate curriculum at large – must be identified, and goals and strategies developed to address them. Successful CPATH projects will be systemic in nature, address a broad range of issues, and have significant potential to contribute to the transformation and revitalization of undergraduate computing education on a national scale.

• Community Building (CB) Grants;
• Evaluation, Adoption, and Extension (EAE) Grants;
• Transformation (T) Grants; and
• CISE Distinguished Education Fellow (CDEF) Grants.

CPATH proposals that describe partnerships with other organizations with a stake in undergraduate computing education are strongly encouraged, where partner organizations may include industry, professional societies, or other not-for-profit organizations, amongst others.

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The Major Research Instrumentation Program (MRI) is designed to increase access to scientific and engineering equipment for research and research training in our Nation’s organizations of higher education, research museums and non-profit research organizations.

This program seeks to improve the quality and expand the scope of research and research training in science and engineering, and to foster the integration of research and education by providing instrumentation for research-intensive learning environments. The MRI program encourages the development and acquisition of research instrumentation for shared inter- or intra-organizational use and in concert with private sector partners.

The MRI program assists in the acquisition or development of major research instrumentation by organizations that is, in general, too costly for support through other NSF programs. Proposals may be for a single instrument, a large system of instruments, or multiple instruments that share a common or specific research focus.

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This request for applications invites applications for infrastructure grants in support of population research relevant to the mission of the Demographic and Behavioral Sciences Branch (DBSB), Center for Population Research (CPR), NICHD. Applicants may request funds to support infrastructure development and/or research designed to: (1) enhance the quality and quantity of population research conducted at an institution; and (2) develop new research capabilities to advance population research through innovative approaches. A central goal of this program is to facilitate interdisciplinary collaboration and innovation in population research while providing essential and cost-effective core services in support of the development, conduct, and translation of population research based in centers or comparable administrative units.

The primary purposes of the Population Research Infrastructure Program are to provide resources to support and advance research that will improve understanding of the antecedents and consequences of population structure and change, facilitate interdisciplinary collaboration among investigators conducting population-related research and in allied fields, and promote innovative approaches to population research questions. An additional goal is to facilitate interactions among scientists in locations throughout the United States that contribute to the integration and coordination of population research.

The Infrastructure Grant funds infrastructure to support a portfolio of population research housed in or coordinated by a center or other research unit (hereafter, "research unit" or "unit") at an institution. Through this support, the Infrastructure Grant is intended to:

• Produce scientific benefits and cost-efficiencies resulting from cooperation and interaction among a pool of scientists with shared interests in population research and shared infrastructure needs;
• Advance the interdisciplinary reach, innovation, and impact of population research through encouraging the development of new directions and approaches to population research and the aggressive pursuit of scientific opportunities appearing at the boundaries between traditional population research and allied fields; and
• Where appropriate and cost-effective, support infrastructure and activities that broadly serve the field of population research by translating and/or disseminating research findings and research resources.

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The purpose of this funding opportunity is to provide support for Genotyping Facilities to genotype samples from human subjects on whom information is available for conditions/traits of public health importance and relevant environmental exposures for genome-wide association (GWA) genotyping and replication studies, as part of the Genes and Environment Initiative.

The Genes and Environment Initiative (GEI) is a four-year, NIH-wide program proposed in the President's FY2007 budget and currently awaiting Congressional approval. If approved, the program will support efforts to identify major genetic susceptibility factors for diseases of substantial public health impact and to develop technologies for reliable and reproducible measurement of potentially causative environmental exposures. It is being developed and implemented by an NIH-wide GEI Coordinating Committee, administratively led by the National Human Genome Research Institute (NHGRI) and the National Institute of Environmental Health Sciences (NIEHS).

It is anticipated that to accomplish the goals of the GEI-GWA program, each Genotyping Facility will:

• participate in developing genotype data quality assessment procedures and policies with the GEI-GWA Steering Committee, and in consultation with NIH and the GEI Genotyping and Analysis Groups,
• develop procedures to minimize the quantity of DNA required for genotyping, including cost-effective and reproducible methods for genome-wide amplification if needed,
• assess DNA quality of a sample of specimens for each potential study, to inform decisions about which studies to include in GEI-GWA,
• receive specimens from Study Investigators. We anticipate that each Genotyping Facility will receive about 2000 specimens from each of 4-8 studies, for a total of 8,000-16,000 specimens per Genotyping Facility, depending on capacity and performance.

• if appropriate, extract DNA or perform genome-wide amplification,
• do initial DNA fingerprinting, or equivalent procedure, and other standard approaches for sample tracking,
• confirm which SNPs to genotype (or genotyping platform to use) with adequate genomic coverage for genome-wide association studies. At least two Genotyping Facilities will have the capacity to genotype specimens from persons of recent African ancestry with adequate genomic coverage,
• choose which SNPs to genotype, and other types of genetic variation to analyze as appropriate, for follow-up studies, in collaboration with the GEI-GWA Steering Committee and the GEI-GWA Project Scientist,
• genotype the SNPs. Release the genotype data and related data to appropriate databases (such as dbSNP [the National Center for Biotechnology InformationÆs (NCBIÆs) Single Nucleotide Polymorphism database] and GEO [NCBI's Gene Expression Omnibus]). Data should include dbSNP number, assay, frequency in the population under study, and, if applicable, amplicon information, genotype calls, quality scores, and .cel or similar files. Genotyping and data release should be completed as soon as the results have been verified; this is anticipated to be within three months of receiving the DNA. Additional time will be allowed for genotyping samples from certain populations such those from individuals of recent African ancestry,
• participate in genotyping data quality assessment activities, following the procedures and policies agreed on by the GEI-GWA Steering Committee, and in consultation with the NIH and the GEI Genotyping and Analysis Groups,
• work with the GEI-GWA Steering Committee to develop replication and follow-up studies if an association is found, or for replication testing of a subset of associated markers from a prior GWA discovery study, if proposed by a Study Investigator receiving an award through the GEI-GWA program. Plans for replication of GEI-GWA findings include strategies to minimize false negative as well as false positive associations, and should specify and justify the size and number of the replication phases and the criteria for retaining candidate markers from one stage to the next. These plans will likely be the subject of much discussion within the GWA collaborative group, which will work together to develop a consensus strategy for such studies,
• work with each Study Investigator to determine procedures for disposition of remaining specimens from each study,
• assist in interpreting data analyses for individual studies or program-wide, in collaboration with the Study Investigators and the Coordinating Center (such as responding to questions about genotyping and statistical analysis procedures, interpreting genotype data, and writing appropriate sections of reports or manuscripts).

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The purpose of this funding opportunity is to provide support for a Coordinating Center (CC) to serve as a centralized resource to facilitate and support genome-wide association studies and other research activities of the four-year NIH-wide Genes and Environment Initiative (GEI).

The Genes and Environment Initiative (GEI) is a four-year, NIH-wide program proposed in the President's FY2007 budget and currently awaiting Congressional approval. If approved, the program will support efforts to identify major genetic susceptibility factors for diseases of substantial public health impact and to develop technologies for reliable and reproducible measurement of potentially causative environmental exposures. It is being developed and implemented by an NIH-wide GEI Coordinating Committee, administratively led by the National Human Genome Research Institute (NHGRI) and the National Institute of Environmental Health Sciences (NIEHS).

The Coordinating Center funded by this RFA will manage the logistics of the GEI-GWA program in collaboration with the NIH Program Office, including organizing meetings and teleconferences, distributing materials, recording draft minutes for Program Office review, etc. The CC will also be responsible for obtaining reports and other information from the Study Investigators, Genotyping Facilities, and other investigator participants in the GEI-GWA and preparing reports for review by NIH program staff, outside advisors, etc.

Funding will be provided for data analysis, coordination, monitoring, supporting, and logistical activities. No recruitment, data collection, or sample acquisition will be supported by this RFA.

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This solicitation seeks to support research and education in science and engineering that requires the use of high-performance computing systems by providing support for the operation of existing HPC systems. This solicitation is a competitive opportunity for institutions that have significant HPC systems with an expected useful life that extends beyond 2007 and which they wish to make available, through the TeraGrid, to the science and engineering community without restriction to discipline.

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