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National Institutes of Health Genome-Wide Association Studies in the Genes and Environment Initiative - Genotyping Facilities (U01) |
N/A |
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Department of Health and Human Services (DHHS) |
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Notice of Intent Deadline of Sep 28, 2006 Has Passed
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Title
National Institutes of Health Genome-Wide Association Studies in the Genes and Environment Initiative - Genotyping Facilities (U01)
Agencies
Department of Health and Human Services (DHHS)
Description
The purpose of this funding opportunity is to provide support for Genotyping Facilities to genotype samples from human subjects on whom information is available for conditions/traits of public health importance and relevant environmental exposures for genome-wide association (GWA) genotyping and replication studies, as part of the Genes and Environment Initiative.
The Genes and Environment Initiative (GEI) is a four-year, NIH-wide program proposed in the President's FY2007 budget and currently awaiting Congressional approval. If approved, the program will support efforts to identify major genetic susceptibility factors for diseases of substantial public health impact and to develop technologies for reliable and reproducible measurement of potentially causative environmental exposures. It is being developed and implemented by an NIH-wide GEI Coordinating Committee, administratively led by the National Human Genome Research Institute (NHGRI) and the National Institute of Environmental Health Sciences (NIEHS).
It is anticipated that to accomplish the goals of the GEI-GWA program, each Genotyping Facility will:
- participate in developing genotype data quality assessment procedures and policies with the GEI-GWA Steering Committee, and in consultation with NIH and the GEI Genotyping and Analysis Groups,
- develop procedures to minimize the quantity of DNA required for genotyping, including cost-effective and reproducible methods for genome-wide amplification if needed,
- assess DNA quality of a sample of specimens for each potential study, to inform decisions about which studies to include in GEI-GWA,
- receive specimens from Study Investigators. We anticipate that each Genotyping Facility will receive about 2000 specimens from each of 4-8 studies, for a total of 8,000-16,000 specimens per Genotyping Facility, depending on capacity and performance.
Overall, we anticipate that specimens for nine studies will be submitted the first year, three studies the second year, and three studies the third year,
- if appropriate, extract DNA or perform genome-wide amplification,
- do initial DNA fingerprinting, or equivalent procedure, and other standard approaches for sample tracking,
- confirm which SNPs to genotype (or genotyping platform to use) with adequate genomic coverage for genome-wide association studies. At least two Genotyping Facilities will have the capacity to genotype specimens from persons of recent African ancestry with adequate genomic coverage,
- choose which SNPs to genotype, and other types of genetic variation to analyze as appropriate, for follow-up studies, in collaboration with the GEI-GWA Steering Committee and the GEI-GWA Project Scientist,
- genotype the SNPs. Release the genotype data and related data to appropriate databases (such as dbSNP [the National Center for Biotechnology InformationÆs (NCBIÆs) Single Nucleotide Polymorphism database] and GEO [NCBI's Gene Expression Omnibus]). Data should include dbSNP number, assay, frequency in the population under study, and, if applicable, amplicon information, genotype calls, quality scores, and .cel or similar files. Genotyping and data release should be completed as soon as the results have been verified; this is anticipated to be within three months of receiving the DNA. Additional time will be allowed for genotyping samples from certain populations such those from individuals of recent African ancestry,
- participate in genotyping data quality assessment activities, following the procedures and policies agreed on by the GEI-GWA Steering Committee, and in consultation with the NIH and the GEI Genotyping and Analysis Groups,
- work with the GEI-GWA Steering Committee to develop replication and follow-up studies if an association is found, or for replication testing of a subset of associated markers from a prior GWA discovery study, if proposed by a Study Investigator receiving an award through the GEI-GWA program. Plans for replication of GEI-GWA findings include strategies to minimize false negative as well as false positive associations, and should specify and justify the size and number of the replication phases and the criteria for retaining candidate markers from one stage to the next. These plans will likely be the subject of much discussion within the GWA collaborative group, which will work together to develop a consensus strategy for such studies,
- work with each Study Investigator to determine procedures for disposition of remaining specimens from each study,
- assist in interpreting data analyses for individual studies or program-wide, in collaboration with the Study Investigators and the Coordinating Center (such as responding to questions about genotyping and statistical analysis procedures, interpreting genotype data, and writing appropriate sections of reports or manuscripts).
More Information
http://grants1.nih.gov/grants/guide/rfa-files/RFA-HG-06-014.html
Submission Limits
Only one proposal per applicant in response to this RFA.
Deadlines
Internal Notice of Intent |
Sep 28, 2006 |
Notification of Internal Competition |
Sep 29, 2006 |
Internal Pre-proposal |
Oct 12, 2006 |
Results of Internal Competition |
Oct 19, 2006 |
Agency Notice of Intent/Pre-proposal |
N/A |
Agency Proposal |
Nov 29, 2006
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Genome-Wide Association Studies in the Genes and Environment Initiative – Coordinating Center (U01) |
N/A |
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Department of Health and Human Services (DHHS), National Institutes of Health (NIH) |
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Title
Genome-Wide Association Studies in the Genes and Environment Initiative – Coordinating Center (U01)
Agencies
Department of Health and Human Services (DHHS), National Institutes of Health (NIH)
Description
The purpose of this funding opportunity is to provide support for a Coordinating Center (CC) to serve as a centralized resource to facilitate and support genome-wide association studies and other research activities of the four-year NIH-wide Genes and Environment Initiative (GEI).
The Genes and Environment Initiative (GEI) is a four-year, NIH-wide program proposed in the President's FY2007 budget and currently awaiting Congressional approval. If approved, the program will support efforts to identify major genetic susceptibility factors for diseases of substantial public health impact and to develop technologies for reliable and reproducible measurement of potentially causative environmental exposures. It is being developed and implemented by an NIH-wide GEI Coordinating Committee, administratively led by the National Human Genome Research Institute (NHGRI) and the National Institute of Environmental Health Sciences (NIEHS).
The Coordinating Center funded by this RFA will manage the logistics of the GEI-GWA program in collaboration with the NIH Program Office, including organizing meetings and teleconferences, distributing materials, recording draft minutes for Program Office review, etc. The CC will also be responsible for obtaining reports and other information from the Study Investigators, Genotyping Facilities, and other investigator participants in the GEI-GWA and preparing reports for review by NIH program staff, outside advisors, etc.
Funding will be provided for data analysis, coordination, monitoring, supporting, and logistical activities. No recruitment, data collection, or sample acquisition will be supported by this RFA.
More Information
http://grants1.nih.gov/grants/guide/rfa-files/RFA-HG-06-032.html
Submission Limits
Only one proposal per applicant in response to this RFA.
Deadlines
Internal Notice of Intent |
Sep 28, 2006 |
Notification of Internal Competition |
Sep 29, 2006 |
Internal Pre-proposal |
Oct 12, 2006 |
Results of Internal Competition |
Oct 19, 2006 |
Agency Notice of Intent/Pre-proposal |
N/A |
Agency Proposal |
Nov 29, 2006
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High-Performance Computing for Science and Engineering Research and Education: Operations (User Support, System Administration and Maintenance) (HPCOPS) |
NSF 06-599 |
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National Science Foundation (NSF) |
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Notice of Intent Deadline of Sep 21, 2006 Has Passed
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Title
High-Performance Computing for Science and Engineering Research and Education: Operations (User Support, System Administration and Maintenance) (HPCOPS)
Agencies
National Science Foundation (NSF)
Description
Office of Cyberinfrastructure
This solicitation seeks to support research and education in science and engineering that requires the use of high-performance computing systems by providing support for the operation of existing HPC systems. This solicitation is a competitive opportunity for institutions that have significant HPC systems with an expected useful life that extends beyond 2007 and which they wish to make available, through the TeraGrid, to the science and engineering community without restriction to discipline.
More Information
http://www.nsf.gov/pubs/2006/nsf06599/nsf06599.htm
Submission Limits
An organization may submit only one proposal.
Deadlines
Internal Notice of Intent |
Sep 21, 2006 |
Notification of Internal Competition |
Sep 22, 2006 |
Internal Pre-proposal |
Oct 5, 2006 |
Results of Internal Competition |
Oct 12, 2006 |
Agency Notice of Intent/Pre-proposal |
N/A |
Agency Proposal |
Nov 28, 2006
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Global Environment for Networking Innovations (GENI): Establishing the GENI Project Office (GPO) (GENI/GPO) |
NSF 06-601 |
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National Science Foundation (NSF) |
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Notice of Intent Deadline of Sep 21, 2006 Has Passed
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Title
Global Environment for Networking Innovations (GENI): Establishing the GENI Project Office (GPO) (GENI/GPO)
Agencies
National Science Foundation (NSF)
Description
The Global Environment for Networking Innovations (GENI) is an experimental facility concept conceived by the computing research community. GENI promises to support the experimental exploration of robust new networking and distributed systems architectures and services that will revolutionize computing and simultaneously contribute to US competitiveness in IT and economic growth.
In order to support the GENI design and development process, the Directorate for Computer and Information Science and Engineering (CISE) will support the work of a GENI Project Office (GPO). Working closely with the computing research community, the GPO will assume responsibility for completion of all GENI preconstruction planning requirements as described in NSF's Guidelines for Planning and Managing the Major Research Equipment and Facilities Construction Account. Upon successful completion of the multiple stages comprising GENI design, and contingent upon support from NSF management, the National Science Board, the Administration and the Congress, GENI will proceed to the construction phase with funding provided from the agency’s Major Research Equipment and Facilities Construction (MREFC) account.
It is anticipated that the GPO will then have full responsibility for overseeing the construction of the facility, ensuring that GENI is delivered on time and within budget. Upon successful GENI construction and commissioning, the GPO may subsequently operate the facility in service to the computing research community.
To ensure that all GENI activities are driven by fundamental research opportunities in networking and distributed systems, the GPO will work closely with the computing research community in all aspects of the design, development, construction and operation of GENI. The community’s research interests in GENI will be represented by a GENI Science Council (GSC) comprised of research leaders in networking and distributed systems; the GSC will be chartered and supported by the NSF-funded Computing Community Consortium. The GPO will work in partnership with the GSC in all aspects of GENI design, development, construction and operation. The GSC will also develop a GENI Science Plan, a “living document†that will evolve over time as new scientific opportunities and challenges are identified.
More Information
http://www.nsf.gov/pubs/2006/nsf06601/nsf06601.htm
Submission Limits
An organization may participate in no more than one GENI/GPO proposal submitted to this competition. The submission of collaborative proposals as defined in NSF’s Grant Proposal Guide is not permitted. An individual may appear as PI, co-PI, Senior Personnel or Consultant on no more than one GENI/GPO proposal submitted to this competition.
Deadlines
Internal Notice of Intent |
Sep 21, 2006 |
Notification of Internal Competition |
Sep 22, 2006 |
Internal Pre-proposal |
Oct 5, 2006 |
Results of Internal Competition |
Oct 12, 2006 |
Agency Notice of Intent/Pre-proposal |
Oct 25, 2006 |
Agency Proposal |
Dec 15, 2006
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Active Nanostructures and Nanosystems (ANN) |
NSF 06-595 |
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National Science Foundation (NSF) |
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Notice of Intent Deadline of Sep 7, 2006 Has Passed
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Title
Active Nanostructures and Nanosystems (ANN)
Agencies
National Science Foundation (NSF)
Description
The National Science Foundation (NSF) announces a program on collaborative research and education in the area of active nanostructures, nanosystems, and on the long-term societal change associated with these innovations. Active nanostructures change or evolve their structure, property, or function during their operation. The goal of this program is to support fundamental research and catalyze synergistic science and engineering research and education in several emerging areas of nanoscale science and engineering, including:
- Active nanostructures;
- Nanosystems with improved functionality and new architectures;
- Hierarchical nanomanufacturing; and
- Long-term societal and educational implications of scientific and technological advances on the nanoscale.
This solicitation provides support for Nanoscale Interdisciplinary Research Teams (NIRT) and Nanoscale Exploratory Research (NER). Other research and education projects in nanoscale science and engineering will continue to be supported in the relevant Programs and Divisions.
Nanoscale Interdisciplinary Research Teams (NIRT): NIRT proposals may be submitted by a single organization or a group of organizations consisting of a lead organization in partnership with one or more partner organizations. Principal investigators are encouraged to form synergistic collaborations among researchers, and with private and public sector organizations, government laboratories, and scientists and engineers at foreign organizations where appropriate, though no funds will be provided to those organizations. At least three PIs and co-PIs, all with funded time committed in the budget, must be listed on the cover page or on the budget page of the proposal. The maximum number of PIs and co-PIs is five; other participants may be listed in the project summary and on the budget pages.
Nanoscale Exploratory Research (NER): Proposals may be submitted by U.S. academic institutions with undergraduate and/or Ph.D. programs in disciplines usually supported by NSF. Research may be proposed by individual investigators or by small groups from academic institutions. Synergistic collaborations among researchers, and collaborations or partnerships with private or public sector organizations or government laboratories are encouraged when appropriate. Prospective proposers are encouraged to contact one of the program officers listed in this solicitation for additional guidance on the suitability of their NER submission if there are questions.
More Information
http://www.nsf.gov/pubs/2006/nsf06595/nsf06595.htm
Submission Limits
A. Nanoscale Interdisciplinary Research Teams (NIRT): An organization – a university, or a campus in a multi-campus university -- may submit no more than two (2) proposals on which it is the lead organization in response to this solicitation. The same organization may be a collaborative partner in any number of other multi-organization group proposals in which it is not the lead.
B. Nanoscale Exploratory Research (NER): An organization – a university or a campus in a multi-campus university -- may submit no more than two (2) proposals on which it is the lead organization in response to this NER solicitation. An exception is made for an additional NER proposal that may be submitted in "Societal and Educational Issues Associated with Long-term Research Science and Engineering Advances" (see Research and Education Themes in Section II). At least one NER proposal submitted by an organization must have a P.I. or co-P.I. at the level of assistant professor or equivalent.
Deadlines
Internal Notice of Intent |
Sep 7, 2006 |
Notification of Internal Competition |
Sep 8, 2006 |
Internal Pre-proposal |
Sep 28, 2006 |
Results of Internal Competition |
Oct 10, 2006 |
Agency Notice of Intent/Pre-proposal |
N/A |
Agency Proposal |
Nov 15, 2006
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Camille Dreyfus Teacher-Scholar Awards Program |
N/A |
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Camille and Henry Dreyfus Foundation |
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Notice of Intent Deadline of Aug 24, 2006 Has Passed
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Title
Camille Dreyfus Teacher-Scholar Awards Program
Agencies
Camille and Henry Dreyfus Foundation
Description
The Camille and Henry Dreyfus Foundation established the Camille and Henry Dreyfus Teacher-Scholar Awards Program to strengthen the teaching and research careers of talented young faculty in the chemical sciences. Based on institutional nominations, the program was designed to provide discretionary funding to faculty at early stages in their careers. Criteria for selection included a commitment to education and an independent body of scholarship that signaled the promise of continuing outstanding contributions to both research and teaching. The Camille Dreyfus Teacher-Scholar Awards Program is judged primarily on individual research attainment and promise, but evidence of excellence in teaching is also expected.
More Information
http://www.dreyfus.org/tc.shtml
Submission Limits
Institutions may submit only one nomination for the Camille Dreyfus Teacher-Scholar program annually.
Deadlines
Internal Notice of Intent |
Aug 24, 2006 |
Notification of Internal Competition |
Aug 25, 2006 |
Internal Pre-proposal |
Sep 28, 2006 |
Results of Internal Competition |
Oct 6, 2006 |
Agency Notice of Intent/Pre-proposal |
N/A |
Agency Proposal |
Nov 9, 2006
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High Performance Computing Acquisition: Towards a Petascale Computing Environment for Science and Engineering |
NSF 05-625 |
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National Science Foundation (NSF) |
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Notice of Intent Deadline of Aug 24, 2006 Has Passed
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Title
High Performance Computing Acquisition: Towards a Petascale Computing Environment for Science and Engineering
Agencies
National Science Foundation (NSF)
Description
NSF’s five-year goal for high performance computing (HPC) is to enable petascale science and engineering through the deployment and support of a world-class HPC environment comprising the most capable combination of HPC assets available to the academic community. By the year 2010, the petascale HPC environment will enable investigations of computationally challenging problems that require computing systems capable of delivering sustained performance approaching 1015 floating point operations per second (petaflops) on real applications, that consume large amounts of memory, and/or that work with very large data sets. Among other things, researchers will be able to perform simulations that are intrinsically multi-scale or that involve the simultaneous interaction of multiple processes.
HPC Resource Providers - those organizations willing to acquire, deploy and operate HPC systems in service to the broad science and engineering research and education community - play a key role in the provision and support of a national HPC environment. With this solicitation, NSF requests proposals from organizations willing to serve as HPC Resource Providers, and who propose to acquire and deploy a new, and/or upgrade an existing, HPC system.
Competitive HPC systems will:
- Enable researchers to work on a range of computationally-challenging science and engineering applications;
- Incorporate reliable, robust system software essential to optimal sustained performance; and
- Provide a high degree of stability and usability.
A robust and effective HPC acquisition process, driven by the requirements of the science and engineering research and education community, is one of the key elements of NSF’s HPC strategy. System performance on an appropriate set of benchmarks will thus be a key factor in system selection. These benchmarks will be designed to capture the salient attributes of those science and engineering applications placing the most stringent demands on the systems to be provisioned.
More Information
http://www.nsf.gov/pubs/2005/nsf05625/nsf05625.htm
Submission Limits
An organization may submit up to two proposals.
Deadlines
Internal Notice of Intent |
Aug 24, 2006 |
Notification of Internal Competition |
Aug 25, 2006 |
Internal Pre-proposal |
Sep 28, 2006 |
Results of Internal Competition |
Oct 6, 2006 |
Agency Notice of Intent/Pre-proposal |
N/A |
Agency Proposal |
Nov 30, 2006
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Partnerships for International Research and Education (PIRE) |
NSF 06-589 |
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National Science Foundation (NSF) |
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Notice of Intent Deadline of Aug 24, 2006 Has Passed
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Title
Partnerships for International Research and Education (PIRE)
Agencies
National Science Foundation (NSF)
Description
Partnerships for International Research and Education (PIRE) seeks to catalyze a cultural change in U.S. institutions by establishing innovative models for international collaborative research and education. The program will enable U.S. institutions to establish collaborative relationships with international groups or institutions in order to engender new knowledge and discoveries at the frontier and to promote the development of a globally-engaged, U.S. scientific and engineering workforce. International partnerships are, and will be, increasingly indispensable in addressing many critical science and engineering problems. As science and engineering discoveries result more and more from international collaboration, U.S. researchers and educators must be able to operate effectively in teams comprised of partners from different nations and cultural backgrounds. The program supports forward-looking research whose successful outcome results from all partners – U.S. and foreign – providing unique contributions to the research endeavor. It is also intended to facilitate greater student preparation for and participation in international research collaboration, and to contribute to the development of a diverse, globally-engaged, U.S. science and engineering workforce.
More Information
http://www.nsf.gov/pubs/2006/nsf06589/nsf06589.htm
Submission Limits
Three (3) preliminary proposals per eligible institution. Invitation to submit a full proposal is based on merit review of the preliminary proposal and will be BY INVITATION ONLY. There is no limit on the number of full proposals on which an institution may participate as non-lead institution.
Deadlines
Internal Notice of Intent |
Aug 24, 2006 |
Notification of Internal Competition |
Aug 28, 2006 |
Internal Pre-proposal |
Sep 14, 2006 |
Results of Internal Competition |
Sep 20, 2006 |
Agency Notice of Intent/Pre-proposal |
Oct 30, 2006 |
Agency Proposal |
Feb 28, 2007
(invitation only!) |
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NINDS Institutional Center Core Grants to Support Neuroscience Research |
N/A |
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Department of Health and Human Services (DHHS), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) |
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Notice of Intent Deadline of Aug 3, 2006 Has Passed
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Title
NINDS Institutional Center Core Grants to Support Neuroscience Research
Agencies
Department of Health and Human Services (DHHS), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH)
Description
The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for Center Core Grants to support neuroscience research. The purpose of this program is to advance the NINDS mission to promote understanding and treatment of neurological disorders by providing core research facilities that are not otherwise available. This support, by providing more accessible resources, is expected to assure a greater productivity than would be possible from the separate projects. An applicant organization is eligible for a maximum of one NINDS Center Core Grant.
NINDS Center Core Grants will support centralized resources and facilities shared by investigators with existing NINDS-funded research projects. Each center will be composed of one or more research cores, each of which will enrich the effectiveness of ongoing research, and promote new research directions. A Center Core Grant will support individual neuroscience research projects by providing necessary resources and performing required services that would be difficult or impractical to provide in individual labs. Center Core Grants will foster a cooperative and interactive research environment through which multidisciplinary approaches to neuroscience problems and joint research efforts will be stimulated. The applicant organization is encouraged to consider a plan to co-fund the center, in order to maximize its utility and effectiveness.
More Information
http://grants1.nih.gov/grants/guide/pa-files/PAR-05-070.html
Submission Limits
Limited applications accepted. An organization may submit only one application.
Deadlines
Internal Notice of Intent |
Aug 3, 2006 |
Notification of Internal Competition |
Aug 4, 2006 |
Internal Pre-proposal |
Aug 29, 2006 |
Results of Internal Competition |
Sep 1, 2006 |
Agency Notice of Intent/Pre-proposal |
N/A |
Agency Proposal |
Oct 1, 2006
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Instrumentation for Materials Research – Major Instrumentation Projects |
NSF 05-513 |
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National Science Foundation (NSF) |
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Notice of Intent Deadline of Aug 3, 2006 Has Passed
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Title
Instrumentation for Materials Research – Major Instrumentation Projects
Agencies
National Science Foundation (NSF)
Description
The Instrumentation for Materials Research - Major Instrumentation Project (IMR-MIP) program in the Division of Materials Research provides support for the design and construction of major instruments costing more than $2 million at major U.S. facilities. The program also supports the development of detailed conceptual and engineering design for new tools for materials preparation or characterization at major national facilities. Such instruments may include, for example, neutron beam lines, synchrotron beam lines, and high field magnets, as well as development of detectors and preparation environments necessary to support materials research.
The program supports two types of awards: Conceptual and Engineering Design (CED) awards and Construction (CNST) awards. A CED award will enable the proposer to do the necessary engineering design of the instrument. A CNST proposal may only be submitted after a satisfactory engineering design of the instrument has been completed and has been approved by both the facility at which the instrument will be situated and by NSF. The program does not provide operating funds for projects it supports through this solicitation. Operational costs must be supported either by the facility at which the instrument is located or through some other source.
More Information
http://www.nsf.gov/pubs/2005/nsf05513/nsf05513.htm
Submission Limits
An institution may submit at most one IMR-MIP proposal in a given year, whether for Conceptual and Engineering Design (CED) or for Construction (CNST).
Deadlines
Internal Notice of Intent |
Aug 3, 2006 |
Notification of Internal Competition |
Aug 4, 2006 |
Internal Pre-proposal |
Aug 24, 2006 |
Results of Internal Competition |
Aug 30, 2006 |
Agency Notice of Intent/Pre-proposal |
N/A |
Agency Proposal |
Oct 16, 2006
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Anyone wishing to submit a proposal for one of these programs should click on the appropriate link in the list above. To expedite the process of planning an internal competition, please submit your notice of intent as soon as you know you have an interest in the funding program. You are only required to include the name of the Principal Investigator, any co-PI's, and the subject or title of the proposed project. The deadline for the internal notice of intent is indicated above.